Bone morphogenetic protein 5

Identifiers

BMP5; MGC34244

External IDs

OMIM: 112265 MGI: 88181 HomoloGene: 22412 GeneCards: BMP5 Gene

Gene Ontology
Molecular function	• cytokine activity • growth factor activity • BMP receptor binding
Cellular component	• cellular_component • extracellular region • extracellular space
Biological process	• skeletal system development • ossification • pattern specification process • cell differentiation • male genitalia development • growth • cartilage development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
55.62 – 55.74 Mb

Chr 9:
75.62 – 75.75 Mb

PubMed search

[1]

[2]

Bone morphogenetic protein 5 is a protein that in humans is encoded by the BMP5 gene.^[1]^[2]^[3]

The protein encoded by this gene is member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain cancers. Like other BMP's BMP5 is inhibited by chordin and noggin. It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver.

This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.^[3]

References

^ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Dec 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.
^ Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ (Mar 2003). "Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons". BMC Neurosci 2: 12. doi:10.1186/1471-2202-2-12. PMC 56999. PMID 11580864. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=56999.
^ ^a ^b "Entrez Gene: BMP5 bone morphogenetic protein 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=653.

Celeste AJ, Iannazzi JA, Taylor RC et al. (1991). "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9843–7. doi:10.1073/pnas.87.24.9843. PMC 55270. PMID 2263636. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55270.
Sakaue M, Kitazawa S, Nishida K et al. (1996). "Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter". Biochem. Biophys. Res. Commun. 221 (3): 768–72. doi:10.1006/bbrc.1996.0671. PMID 8630036.
You L, Kruse FE, Pohl J, Völcker HE (1999). "Bone morphogenetic proteins and growth and differentiation factors in the human cornea". Invest. Ophthalmol. Vis. Sci. 40 (2): 296–311. PMID 9950587.
Imai N, Iwai A, Hatakeyama S et al. (2001). "Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification". Pathol. Int. 51 (8): 643–8. doi:10.1046/j.1440-1827.2001.01243.x. PMID 11564221.
Jin Y, Lu HB, Liong E et al. (2002). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histol. Histopathol. 16 (4): 1013–9. PMID 11642720.
Cohen A, Mulas R, Seri M et al. (2002). "Meier-Gorlin syndrome (ear-patella-short stature syndrome) in an Italian patient: clinical evaluation and analysis of possible candidate genes". Am. J. Med. Genet. 107 (1): 48–51. doi:10.1002/ajmg.10083. PMID 11807867.
Jiang FX, Stanley EG, Gonez LJ, Harrison LC (2002). "Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells". J. Cell. Sci. 115 (Pt 4): 753–60. PMID 11865031.
Luo J, Dunn T, Ewing C et al. (2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis". Prostate 51 (3): 189–200. doi:10.1002/pros.10087. PMID 11967953.
Wordinger RJ, Agarwal R, Talati M et al. (2002). "Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues". Mol. Vis. 8: 241–50. PMID 12131877.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Nakayama N, Han CY, Cam L et al. (2004). "A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage". Development 131 (1): 229–40. doi:10.1242/dev.00901. PMID 14660436.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Xu WP, Shiba H, Mizuno N et al. (2005). "Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells". Cell Biol. Int. 28 (10): 675–82. doi:10.1016/j.cellbi.2004.06.004. PMID 15516325.
Bobinac D, Marić I, Zoricić S et al. (2005). "Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer". Croat. Med. J. 46 (3): 389–96. PMID 15861517.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Bramlage CP, Häupl T, Kaps C et al. (2006). "Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis". Arthritis Res. Ther. 8 (3): R58. doi:10.1186/ar1923. PMC 1526630. PMID 16542506. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1526630.
Wilkins JM, Southam L, Price AJ et al. (2007). "Extreme context specificity in differential allelic expression". Hum. Mol. Genet. 16 (5): 537–46. doi:10.1093/hmg/ddl488. PMID 17220169.

Cell signaling: TGF beta signaling pathway

TGF beta superfamily of ligands	TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin and inhibin, Anti-müllerian hormone, Nodal)

TGF beta receptors (Activin, BMP)	TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) · ACVRL1 · BMPR1 (BMPR1A · BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) · AMHR2 · BMPR2 TGFBR3: betaglycan

Transducers/SMAD	R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) · I-SMAD (SMAD6, SMAD7) · SMAD4

Ligand inhibitors	Cerberus · Chordin · DAN · Decorin · Follistatin · Gremlin · Lefty · LTBP1 · Noggin · THBS1

Coreceptors	BAMBI · Cripto

Other	SARA

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Bone morphogenetic protein 5

References

Further reading